关键词: 肾功能不全, 慢性, 腹膜透析, 卒中

Abstract: ObjectiveTo investigate the risk factors in patients with acute stroke  receiving peritoneal dialysis（PD）. MethodsThe  clinical data of 129 cases with endstage renal disease receiving continuous ambulatory peritoneal dialysis(CAPD) for more than 3 months were collected for retrospective analysis. A total of 25 cases in PD with acute stroke were chosen as study group while the other 104 cases in peritoneal dialysis without stroke served as control group. The clinical data included age， body mass index(BMI)， duration of PD， hypertension， hemoglobin， serum albumin(Alb)， blood urea nitrogen(BUN)， serum creatinine(Scr)， corrected serum calcium，  serum phosphate，  serum intact parathyroid   hormone(iPTH)， total cholesterol， triglycerides，PD type and Kt/V  and their relationships with stroke were analyzed.ResultsThe  levels of Alb， BUN， iPTH and Kt/V in study group  were significantly lower than those in control group， while age and triglycerides were significantly higher (P<0.05). Multivariate  logistic regression analysis showed that age (P=0.044)， hypertension(P=0.007)， Alb(P=0.009)， PD type(P=0.005) and triglycerides (P=0.005) were independent risk or protective factors for stroke in PD patients. Hypertension (P=0.007) and triglycerides (P=0.034) were independent risk factors for cerebral hemorrhage or cerebral hematoma in PD patients. Age (P=0.021) and Alb (P=0.025) were independent risk or protective factors for cerebral infarction in  PD  patients. ConclusionThe high morbidity of stroke in  PD  patients has close correlation with uncontrolled hypertension， low serum albumin， lipid metabolism disorder， iPTH and incomplete dialysis.  Low calcium dialysate improves calcium phosphate metabolism and calcium overload， it can significantly reduce the incidence of stroke in endstage renal patients receiving PD.

Key words: renal , insufficiency, chronic; , peritoneal dialysis; , stroke