Abstract: Objective  To investigate the clinical characteristics and risk factors in type 2 diabetic nephropathy. Methods  A total of 3 251 type 2 diabetes mellitus patients were chosen to carry on a retrospective casecontrol study.According to nephropathy or not，the patients were divided into DN group and nonDN group，general information and laboratory examination were compared between. The related risk factors of type 2 diabetic nephropathy were analyzed by logistic regression.Results  Disease course，body mass index(BMI)，systolic blood pressure(SBP)，diasstolic blood pressure(DBP)，total cholesterol(TC)， triglyceride(TG)，low density lipoprotein cholesterol(LDLC)，creatinine(Cr)，serum uric acid(SUA)，fasting blood glucose(FPG)，hemoglobin A1c(HbA1c)， fibrinogen  in DN group were significantly higher than those of nonDN group (P<0.05).Logistic regression analysis showed that disease course two groups， smoking， BMI，SBP， SUA， HbAlc and TG were risk factors of type 2 diabetic nephropathy.Conclusion  The risk factors of type 2 diabetic nephropathy are disease  course， smoking， BMI，SBP， SUA， HbAlc and TG， early screening for highrisk factors are recommended to reduce the occurrence of type 2 diabetic nephropathy.

Key words: diabetes mellitus, type 2, diabetic nephropathy, risk factors