Correlation between serum uric acid levels and coronary artery calcification severity in patients with stable angina pectoris

doi:10.3969/j.issn.1004-583X.2025.03.003

Abstract

Abstract:

Objective To investigate the correlation between serum uric acid (SUA) levels and coronary artery calcification (CAC) severity in patients with stable angina pectoris (SAP), thus providing a basis for the diagnosis and assessment of CAC. Methods A total of 125 patients diagnosed with SAP in Beijing Renhe Hospital from September 2021 to August 2024 were recruited, and all patients were given CTA scan in the hospital. After calculating the Agatston coronary artery calcification score (CACS), the patients were divided into non-calcification group (CACS=0, n=11), less calcification group (1≤CACS≤10, n=34), mild calcification group (11≤CACS≤100, n=26), moderate calcification group (101≤CACS≤399, n=36), severe calcification group (CACS≥400, n=18). The clinical data of each group were compared. Logistic regression analysis was employed to screen the influencing factors of CAC. Correlation analysis was used to explore the correlation between SUA level and other indicators. Receiver operating characteristic (ROC) curve analysis was applied to evaluate the value of SUA level in predicting CAC severity. Results There were no significant differences in gender, age, drinking history, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and lipoprotein (α) (Lp[α]) levels among the five groups (P>0.05). There were statistically significant differences in the proportions of hypertension, diabetes and smoking, and levels of total cholesterol (TC) and SUA (P<0.05). The results of ordinal logistic regression analysis showed that hypertension history, diabetes history, smoking history, drinking history, TG, TC, LDL-C, LP (α) and SUA were all risk factors for CAC (P<0.05). Correlation analysis showed that SUA level was positively correlated with TC, LDL-C, LP (α) and CAC severity (P<0.05). The area under ROC curve (AUC) of SUA level in predicting CAC severity was 0.884(95%CI: 0.816-0.951), with the cutoff value of 367.5 μmol/L, the sensitivity of 81.6%, and the specificity of 90.9%. Conclusion SUA levels in SAP patients are positively correlated with CAC severity, making SUA an independent risk factor with certain diagnostic value for CAC.

Key words: angina, stable, vascular calcification, coronary vessels, serum uric acid, correlation analysis

CLC Number:

R541.4

Liu Shenghua. Correlation between serum uric acid levels and coronary artery calcification severity in patients with stable angina pectoris[J]. Clinical Focus, 2025, 40(3): 211-216.

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https://lchc.magtechjournal.com/EN/Y2025/V40/I3/211

Figures/Tables 5

References 29

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组别		例数	男性[例(%)]		年龄(岁)		高血压病史[例(%)]		糖尿病史[例(%)]			吸烟史[例(%)]
无钙化组		11	6(54.6)		63.09±9.56		3(27.3)		4(36.4)			1(9.1)
少量钙化组		34	18(52.9)		61.85±10.90		9(26.5)		10(29.4)			7(20.6)
轻度钙化组		26	13(50.0)		58.81±8.80		9(34.6)		11(42.3)			10(38.5)
中度钙化组		36	18(50.0)		64.67±9.80		17(47.2)		20(55.6)^*#			14(38.9)
重度钙化组		18	11(61.1)		63.11±11.31		15(83.3)^*#△▲		13(72.2)^*#			13(72.2)^*#△▲
F/χ²值			0.58		1.32		17.90		10.61			17.41
P值			0.97		0.26		<0.01		0.03			<0.01
组别	饮酒史[例(%)]			TG(mmol/L)		TC(mmol/L)		LDL-C(mmol/L)		LP(α)(mg/dL)	SUA(μmol/L)
无钙化组	2(18.2)			1.13±0.31		3.73±0.91		3.04±0.86		12.01±4.20	343.5.20±28.23
少量钙化组	8(23.5)			1.32±0.42		4.65±1.00		3.14±0.82		12.02±2.28	385.30±41.41
轻度钙化组	11(42.3)			1.35±0.27		5.16±1.26^*		3.29±0.93		12.80±3.45	402.20±59.49^*
中度钙化组	14(38.9)			1.43±0.36		5.47±0.77^*#		3.62±1.05		13.57±2.69	455.20±50.75^*#
重度钙化组	11(61.1)			1.45±0.19		6.24±0.87^*#△		3.65±0.93		14.83±3.37	499.30±32.23^*#△▲
F/χ²值	9.20			2.51		14.51		0.91		2.41	36.16
P值	0.06			0.05		<0.01		0.11		0.05	<0.01

组别		例数	男性[例(%)]		年龄(岁)		高血压病史[例(%)]		糖尿病史[例(%)]			吸烟史[例(%)]
无钙化组		11	6(54.6)		63.09±9.56		3(27.3)		4(36.4)			1(9.1)
少量钙化组		34	18(52.9)		61.85±10.90		9(26.5)		10(29.4)			7(20.6)
轻度钙化组		26	13(50.0)		58.81±8.80		9(34.6)		11(42.3)			10(38.5)
中度钙化组		36	18(50.0)		64.67±9.80		17(47.2)		20(55.6)^*#			14(38.9)
重度钙化组		18	11(61.1)		63.11±11.31		15(83.3)^*#△▲		13(72.2)^*#			13(72.2)^*#△▲
F/χ²值			0.58		1.32		17.90		10.61			17.41
P值			0.97		0.26		<0.01		0.03			<0.01
组别	饮酒史[例(%)]			TG(mmol/L)		TC(mmol/L)		LDL-C(mmol/L)		LP(α)(mg/dL)	SUA(μmol/L)
无钙化组	2(18.2)			1.13±0.31		3.73±0.91		3.04±0.86		12.01±4.20	343.5.20±28.23
少量钙化组	8(23.5)			1.32±0.42		4.65±1.00		3.14±0.82		12.02±2.28	385.30±41.41
轻度钙化组	11(42.3)			1.35±0.27		5.16±1.26^*		3.29±0.93		12.80±3.45	402.20±59.49^*
中度钙化组	14(38.9)			1.43±0.36		5.47±0.77^*#		3.62±1.05		13.57±2.69	455.20±50.75^*#
重度钙化组	11(61.1)			1.45±0.19		6.24±0.87^*#△		3.65±0.93		14.83±3.37	499.30±32.23^*#△▲
F/χ²值	9.20			2.51		14.51		0.91		2.41	36.16
P值	0.06			0.05		<0.01		0.11		0.05	<0.01

变量	赋值
因变量
CAC	无钙化=1,少量钙化=2,轻度钙化=3,中度钙化=4,重度钙化=5
自变量
既往史
高血压病史	有=1,无=0
糖尿病史	有=1,无=0
个人史
吸烟史	有=1,无=0
饮酒史	有=1,无=0
TG	连续变量
TC	连续变量
LDL-C	连续变量
LP(α)	连续变量
SUA	连续变量

变量	赋值
因变量
CAC	无钙化=1,少量钙化=2,轻度钙化=3,中度钙化=4,重度钙化=5
自变量
既往史
高血压病史	有=1,无=0
糖尿病史	有=1,无=0
个人史
吸烟史	有=1,无=0
饮酒史	有=1,无=0
TG	连续变量
TC	连续变量
LDL-C	连续变量
LP(α)	连续变量
SUA	连续变量

因素	回归系数	标准误	Wald χ²值	P值	OR值	95%可信区间
高血压病史	1.309	0.342	14.622	<0.05	3.702	0.638~1.979
糖尿病史	1.027	0.332	9.591	<0.05	2.793	0.377~1.677
吸烟史	1.347	0.353	14.574	<0.05	3.846	0.656~2.039
饮酒史	0.931	0.340	7.480	<0.05	2.537	0.264~1.598
TG	1.125	0.472	5.697	<0.05	3.080	0.201~2.050
TC	1.204	0.164	54.199	<0.05	3.333	0.844~1.525
LDL-C	0.448	0.174	6.614	<0.05	1.565	0.107~0.789
LP(α)	0.168	0.055	9.388	<0.05	1.183	0.061~0.276
SUA	0.027	0.003	59.216	<0.05	1.027	0.020~0.033