Abstract:

Objective To investigate the types of pathogens, causes of infection and prognosis of peritoneal dialysis associated peritonitis (PDAP) in a single center. Methods A total of 412 PD patients with long-term regular follow-up in the Peritoneal Dialysis Clinic of Gansu Provincial Hospital from January 2015 to January 2024 were selected. According to the occurrence of PDAP, the patients were divided into the PDAP group (n=91) and control group (n=321). The general conditions and experimental data of the two groups were compared, and the types of pathogenic bacteria, causes of infection and prognosis of PDAP were analyzed. Results Compared with the control group, patients in the PDAP group had significantly older age and onset of PD, and lower prealbumin, plasma albumin and hemoglobin (P<0.05). A total of 121 cases of peritonitis occurred in 91 patients in the PDAP group. The positive rate of bacterial culture in PDAP group was 84.30%. Gram-positive bacteria accounted for 83.33%, which was the main pathogenic bacteria of PDAP, among which Staphylococcus epidermidis was the main pathogen, accounting for 41.18%. In the PDAP group, 39.67% of the causes of infection were unknown, 24.79% were related to operation, and 22.31% were unclean diet. The cure rate of peritonitis was 89.26%, and the rate of extubation to hemodialysis was 10.74%. Conclusion Except for unknown reasons, PDAP in the peritoneal dialysis center of Gansu Provincial People 's Hospital was mostly related to PD operation, followed by eating overnight food. It is necessary to strengthen the standardization of patient operation and health education of diet.

Key words: peritonitis, peritoneal dialysis, peritonitis pathogens