关键词: 耐药性癫痫, 病因, 病程, 治疗结果

Abstract:

Objective To analyze the influence of etiology and preoperative course of disease on the curative effect of children with drug-resistant epilepsy (DRE) in a single center. Methods A retrospective analysis was conducted on 48 pediatric patients with DRE admitted to Xiamen Humanity Hospital Affiliated to Fujian Medical University between January 1, 2021, and December 31, 2022. Clinical data of the patients were collected and they were followed up to analyze the relationship between different etiologies, preoperative disease duration, and treatment outcomes. Additionally, the evaluation of postoperative efficacy was explored. Results There was no significant difference in the efficacy between subgroups of genetic etiology and structural etiology (OR=4.754, 95%CI=0.980-23.074, P=0.053). Logistic regression analysis showed that OR>1, suggesting that genetic causes may increase the risk of poor efficacy compared with structural causes. For every one-year increase in the course of disease before surgery, the treatment effect was significantly improved (P<0.05). Conclusion Genetic causes are associated with an increased risk of poor prognosis of DRE compared to structural causes. For children with non-early-onset epilepsy and lighter seizure burden, a longer preoperative course indicates a better surgical effect.

Key words: drug resistant epilepsy, pathogenesis, course, treatment outcome